High rate of aneuploidy in luteinized granulosa cells obtained from follicular fluid in women who underwent controlled ovarian hyperstimulation
Tarih
2005Yazar
Topcuoglu, A
Irez, T
Kaleli, Semih
Yanikkaya-Demirel, G
Erel, CT
Senturk, LM
Üst veri
Tüm öğe kaydını gösterÖzet
We performed a prospective study to detect the cell cycle changes in luteinized granulosa cells in patients undergoing controlled ovarian stimulation with GnRH analog and gonadotropin therapy. Aneuploid DNA content was observed in 37 of 70 women (52.9%), and multiple logistic regression analysis revealed that only the dose of gonadotropins used significantly predicted the ploidy status of granulosa cells, which indicates that ovarian hyperstimulation in IVF treatment might be detrimental for the DNA content of granulosa cells.
Koleksiyonlar
- Makale [92796]