Polymorphisms of the DNA Repair Genes XPD and XRCC1 and the Risk of Age-Related Macular Degeneration
Tarih
2010Yazar
Seven, Mehmet
Guven, Gulgun S.
Guven, Mehmet
Gorgun, Ebru
ÜNAL, MUSTAFA
Yenerel, Melda
Tatlipinar, Sinan
Yuksel, Adnan
Batar, Bahadir
Üst veri
Tüm öğe kaydını gösterÖzet
PURPOSE. Oxidative stress seems to be an important factor in the development of age-related macular degeneration (AMD). The role of DNA repair mechanisms has also received attention recently in AMD pathogenesis. This case-control study was conducted to determine the frequency of polymorphisms in two DNA repair enzyme genes, xeroderma pigmentosum complementation group D (XPD), codons 312 and 751, and x-ray cross-complementing group 1 (XRCC1), codons 194 and 399, in patients with AMD and in disease-free control subjects.
Koleksiyonlar
- Makale [92796]