Everolimus dosing recommendations for tuberous sclerosis complex-associated refractory seizures
Tarih
2018Yazar
Wiemer-Kruel, Adelheid
Kohrman, Michael H.
Wong, Michael
Milh, Mathieu
French, Jacqueline A.
Grosch, Kai
Cheung, Wing
Coello, Neva
Voi, Maurizio
Yapici, Zuhal
Franz, David N.
Lawson, John A.
Brandt, Christian
Üst veri
Tüm öğe kaydını gösterÖzet
ObjectiveThe present analysis examined the exposure-response relationship by means of the predose everolimus concentration (C-min) and the seizure response in patients with tuberous sclerosis complex-associated seizures in the EXIST-3 study. Recommendations have been made for the target C-min range of everolimus for therapeutic drug monitoring (TDM) and the doses necessary to achieve this target C-min.
Koleksiyonlar
- Makale [92796]