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Everolimus dosing recommendations for tuberous sclerosis complex-associated refractory seizures

dc.contributor.authorWiemer-Kruel, Adelheid
dc.contributor.authorKohrman, Michael H.
dc.contributor.authorWong, Michael
dc.contributor.authorMilh, Mathieu
dc.contributor.authorFrench, Jacqueline A.
dc.contributor.authorGrosch, Kai
dc.contributor.authorCheung, Wing
dc.contributor.authorCoello, Neva
dc.contributor.authorVoi, Maurizio
dc.contributor.authorYapici, Zuhal
dc.contributor.authorFranz, David N.
dc.contributor.authorLawson, John A.
dc.contributor.authorBrandt, Christian
dc.date.accessioned2021-03-03T14:30:11Z
dc.date.available2021-03-03T14:30:11Z
dc.date.issued2018
dc.identifier.citationFranz D. N. , Lawson J. A. , Yapici Z., Brandt C., Kohrman M. H. , Wong M., Milh M., Wiemer-Kruel A., Voi M., Coello N., et al., "Everolimus dosing recommendations for tuberous sclerosis complex-associated refractory seizures", EPILEPSIA, cilt.59, sa.6, ss.1188-1197, 2018
dc.identifier.issn0013-9580
dc.identifier.otherav_39ef3e3c-51dd-4d64-9cfb-37a24b916edf
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/42935
dc.identifier.urihttps://doi.org/10.1111/epi.14085
dc.description.abstractObjectiveThe present analysis examined the exposure-response relationship by means of the predose everolimus concentration (C-min) and the seizure response in patients with tuberous sclerosis complex-associated seizures in the EXIST-3 study. Recommendations have been made for the target C-min range of everolimus for therapeutic drug monitoring (TDM) and the doses necessary to achieve this target C-min.
dc.language.isoeng
dc.subjectTıp
dc.subjectKLİNİK NEUROLOJİ
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectNöroloji
dc.titleEverolimus dosing recommendations for tuberous sclerosis complex-associated refractory seizures
dc.typeMakale
dc.relation.journalEPILEPSIA
dc.contributor.departmentCincinnati Children''s Hospital Medical Center , ,
dc.identifier.volume59
dc.identifier.issue6
dc.identifier.startpage1188
dc.identifier.endpage1197
dc.contributor.firstauthorID253750


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