The relationship between UGT1A4 polymorphism and serum concentration of lamotrigine in patients with epilepsy
Author
Ozkaynakci, Aydan
Aker, Rezzan Gulhan
GÖREN, MEHMET ZAFER
Gulcebi, Medine Idrizoglu
Ozkara, Cigdem
Onat, Filiz Yilmaz
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Lamotrigine (LTG) which has a widespread use in epilepsy treatment as an antiepileptic agent is metabolized by UDP-glucuronosyl transferase (UGT) enzymes. In this study, single nucleotide polymorphisms, P24T and L48V, of the UGT1A4 enzyme have been investigated in a Turkish population of patients with epilepsy (n=131) by comparing serum levels of LTG of wild type and polymorphic subjects.
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