Altered cyclin D1 genotype distribution in human sporadic pituitary adenomas.

Author
Ozbek, Uğur
Ersoy, Ismail Hakki
Cagatay, Penbe
Kadioglu, Pınar
Sayıtıoglu, Müge
Ciplak, Nejat
Erensoy, Nevin
Hatımaz, Ozden
Kısacık, Bunyamin
Oz, Buge
Sar, Mehmet
Gazioglu, Nurperi
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Abstract
Background: The cyclin D1 gene (CCND1) is a proto-oncogene playing a critical role in the transition through the G1 ot the S phase of the cell cyle and is overexpressed in many tumors. G870A plymorphism at the exon4/intron4 splicing region of the CCND1 gene may play a role in pituitary tumorigenesis and invasiveness. The objective of this study was to examine CCND1 polymorphism i patients with different types sporadic pituitary adenomas.
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http://hdl.handle.net/20.500.12627/13826
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