Age-Related Co-Expression of BCOR and BCORL1 mRNA in Acute Myeloid Leukemia

Date
2020
Author
Soysal, Teoman
Percin-Pacal, Ferda
Seflekci, Yusuf
Sirma-Ekmekci, Sema
KARAKAŞ, Zeynep
COŞKUN, Feyza
EMRENCE, Zeliha
Ar, Muhlis C.
ABACI, Neslihan
ÜNÜVAR, Ayşegül
Eskazan, Ahmet E.
Elverdi, Tugrul
Salihoglu, Ayse
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Abstract
Background: Acute myeloid leukemia (AML) is an aggressive hematological malignancy caused by a variety of genetic abnormalities and epigenetic dysregulation. The incidence of AML is strongly related to age, with the highest incidence rates being in older adults. The loss of function mutations in BCOR and BCORL1 genes have been identified in AML. BCL6 corepressor (BCOR) and BCL6 corepressor like 1 (BCORL1) are important epigenetic regulators as a member of Polycomb repressive complex 1 (PRC1.1), involved in histone modification processes.
URI
http://hdl.handle.net/20.500.12627/130857
https://doi.org/10.7754/clin.lab.2020.191119
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