Comparison of the efficacy of different methods on the medical treatment of cystic endometrial hyperplasia-pyometra complex in bitches

Abstract

This study aimed to compare the effectiveness of ovariohysterectomy operations with aglepristone and aglepristone+PGF(2 alpha) treatment protocols, preceded by clinical, gynaecological, and ultrasonographical examinations and total blood and hormone analyses in bitches. Furthermore, the influence of initial progesterone (P4) concentrations and uteral diameters on the efficacy of pyometra treatment was determined. Thirty bitches with pyometra were divided into three equal groups: the surgically treated group (OP) and groups treated pharmacologically aglepristone (AL) and with aglepristone+PGF(2 alpha) (AP). A dose of 10 mg/kg of aglepristone was administered subcutaneously on days 1, 2, and 7 and if needed on day 14 (groups AL and AP). The bitches of the AP group received additionally 0.25 mg/kg of PGF(2 alpha), dinoprost trometamin, once every 24 h between days 3 to 7. Eight bitches in the OP group (80%), five bitches (50%) in the AL group, and five bitches (50%) in the AP group recovered. The success ratios we established, ignoring the criteria for treatment acceptance, increased to 60% in the AL group and 83.3% in the AP group when the bitches with P4>2 ng/mL and without ovarian cysts were evaluated and the difference between success ratios of the two groups was found to be insignificant. It has been found that carrying out frequently repeated examinations, pharmacological treatments using aglepristone or aglepristone+PGF(2 alpha) constitutes a safe alternative to ovariohysterectomy in bitches in the dioestrus phase with P4>2 ng/mL and without ovarian cysts.