Serum microRNA expression in pregnancies with preeclampsia
Tarih
2011Yazar
Benian, A.
Aydinli, Kılıç
Zeybek, Y. G.
Akcakaya, P.
Gunel, T.
Ermis, H.
Kalelioglu, I.
Üst veri
Tüm öğe kaydını gösterÖzet
Preeclampsia continues to be a mortal disease of pregnant women throughout the world. Recently, geneticists, allied with obstetricians, have opened new frontiers. MicroRNAs (miRNAs) are members of a class of small, noncoding RNA molecules. They are critical posttranscriptional regulators of gene expression. We extracted circulating miRNA from maternal plasma and quantified mir152 and mir-210. We found up-regulated miR-210 levels as well as down-regulated mir-152 levels in preeclampsia patients. We propose that detection of increased mir-210 levels in maternal serum could be used to improve prediction methods for noninvasive prenatal diagnosis of preeclampsia.
Koleksiyonlar
- Makale [92796]