Protective ventilation with high versus low positive end-expiratory pressure during one-lung ventilation for thoracic surgery (PROTHOR): study protocol for a randomized controlled trial

Author
Loop, T.
Karzai, W.
Krassler, J.
Licker, M. J.
de Abreu, M. Gama
Senturk, M.
Rossaint, R.
Schultz, M. J.
Neto, A. Serpa
Severgnini, P.
Szegedi, L.
Vegh, T.
Voyagis, G.
Zhong, J.
Kiss, T.
Wittenstein, J.
Becker, C.
Birr, K.
Cinnella, G.
Cohen, E.
El Tahan, M. R.
Falcao, L. F.
Gregoretti, C.
Granell, M.
Hachenberg, T.
Hollmann, M. W.
Marczin, N.
Mills, G. H.
Murrell, M. T.
Neskovic, V.
Nisnevitch-Savarese, Z.
Pelosi, P.
Jankovic, R.
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Abstract
Background: Postoperative pulmonary complications (PPC) may result in longer duration of in-hospital stay and even mortality. Both thoracic surgery and intraoperative mechanical ventilation settings add considerably to the risk of PPC. It is unclear if one-lung ventilation (OLV) for thoracic surgery with a strategy of intraoperative high positive end-expiratory pressure (PEEP) and recruitment maneuvers (RM) reduces PPC, compared to low PEEP without RM.
URI
http://hdl.handle.net/20.500.12627/92299
https://doi.org/10.1186/s13063-019-3208-8
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