A rapid and highly sensitive spectrofluorimetric method for the determination of venlafaxine by charge transfer complexation reaction with p-bromanil and p-chloranil

Abstract

Simple, rapid and highly sensitive spectrofluorimetric methods were developed for the determination of venlafaxine in pure and pharmaceutical preparations. The proposed methods were based on the reaction of venlafaxine as n-electron donor with pi-acceptors namely, p-bromanil and p-chloranil. The method for the determination of venlafaxine over a concentration range of 5-100 and 5-150 ng/mL, for p-bromanil and p-chloranil methods, respectively. The intra- and inter-day precisions were satisfactory, the relative standard deviations did not exceed 1.69%. The proposed method was successfully applied to the determination of venlafaxine in its pharmaceutical preparations with good accuracy; the mean recovery percentages were 99.80%. The results were compared favorably with those of the reference method.