Integrated Role of Two Apoliprotein E Polymorphisms on Apolipoprotein B Levels and Coronary Artery Disease in a Biethnic Population

Abstract

Background: Apolipoprotein E (ApoE) plays a major role in lipoprotein metabolism and genetic variability of ApoE confers susceptibility to coronary artery disease (CAD). Beyond variability in the coding region, promoter polymorphisms in the ApoE gene impact on ApoE transcription.