Some 3-hydrazono-2-indolinones and N-Mannich bases as potential anticonvulsants

Abstract

In this study a new series of 3-aryloxy/arylthioxyacetylhydrazono-2-indolinones obtained by condensation,of isatin with aryoxy/arythioxyacetylhydrazines were treated with morpholine and formaldehyde to yield 1-morpholinomethyl-3-aryloxy/arylthioxyacetylhydrazone-2-indolinones. Structures of all the compounds were assigned on the basis of spectral data (UV, IR, H-1-NMR, EIMS) and elemental analyses. Anticonvulsant evaluation of the compounds revealed varying degrees of activity against. pentylenentetrazole induced seizures.