Investigation of Polymorphisms on ABCG2, AA-NAT and FABP3 Genes in the Kivircik Sheep Reared in Three Different Provinces of Turkey

Abstract

In this study mutations located in intron 5 of ABCG2, exon 3 of AA-NAT and exon 2 of FAB3 genes were investigated by PCR based methods in the Kivircik sheep sampled from Bursa, Manisa, and Istanbul provinces of Turkey. All loci investigated were found as polymorphic. While in the ABCG2 and FABP3 loci two alleles and three genotypes were found, in the AA-NAT locus two alleles and two genotypes were detected. In ABCG2 locus allele "-", in AA-NAT allele A, in FABP3 locus allele G were observed as predominant. The frequency values of the predominat alleles at ABCG2, AA-NAT and FABP3 loci were found 0.60, 0.87 and 0.58, respectively. While the whole population investigated exhibits deviation from the Hardy-Weinberg equilibrium for ABCG2 and FABP3 loci, was found at Hardy-Weinberg equilibrium for AA-NAT locus.