Characterization of Minor HA-1 in Patients Who Underwent Living Donor Kidney Transplantation

Abstract

Objectives: The importance of the Human Leukocyte Antigens (HLA) matching is well known in renal transplantation that is one of the best treatment options for end-stage solid organ deficiency. Human Leukocyte Antigens matching between recipient and donor has an influence on graft survey after the renal transplantation. However allogeneic renal transplants between HLA identical siblings might be ended with rejection. Minor histocompatibility antigen (mHag) HA-1 is a nine-amino acid peptide encoded by a diallelic gene on human chromosome 19. mHags have low polymorphisms. Minor histocompatibility antigens are likely to function as potantial risks for graft rejection of HLA-matched solid organ transplantation. In our study, we aimed to investigate the effect of minor HA-1 mismatch on kidney transplant survey.