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Synthesis, characterisation and cytotoxic properties of the N-1,N-4-diarylidene-S-methyl-thiosemicarbazone chelates with Fe(III) and Ni(II)

Date
2007
Author
Atasever, Belkis
Ulkuseven, Bahri
Solakoglu, Zeynep
Erdem-Kuruca, Serap
Bal, Tulay
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Abstract
Reactions of 2-hydroxy-3-methoxy, 2-hydroxy-4-methoxy-benzaldehyde with 3- and 4-methoxy-substituted salicylaidehyde S-methyl-thiosemicarbazones in the presence of FeCl3 and NiCl2 resulted in the corresponding methoxy-substituted N-1,N-4-diarylidene-S-methyl-thiosemicarbazone chelates. Characterisation of the compounds in the [Fe(L)CI] and [Ni(L)] general formula was accomplished by means of elemental analysis, conductivity and magnetic measurements, H-1 NMR, UV-vis, IR and mass spectroscopy. Cytotoxicity and proliferation experiments using K562 chronic myeloid leukemia cell line and ECV 304 human endothelial cell line imply that the iron(111) chelates may have antileukemic effects with 3.5 mu g/dl LD50 dose. (c) 2006 Elsevier Masson SAS. All rights reserved.
URI
http://hdl.handle.net/20.500.12627/75016
https://doi.org/10.1016/j.ejmech.2006.09.004
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Creative Commons Lisansı

İstanbul Üniversitesi Akademik Arşiv Sistemi (ilgili içerikte aksi belirtilmediği sürece) Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

DSpace software copyright © 2002-2016  DuraSpace
Contact Us | Send Feedback
Theme by 
Atmire NV