The effects of age and gender on the relationship between HMGCR promoter-911 SNP (rs33761740) and serum lipids in patients with coronary heart disease

Author
Akadam-Teker, Basak
Yilmaz-Aydogan, Hülya
Ozturk, Oguz
Bugra, Zehra
Teker, Erhan
Cakmak, Huseyin Altug
Kucukhuseyin, Ozlem
Daglar-Aday, Aynur
Coskunpinar, Ender
Kurnaz, Özlem
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Abstract
Background: Hydroxymethylglutaryl-Coenzyme A Reductase (HMGCR) catalyzes the rate-limiting step of cholesterol biosynthesis. This enzyme is the target of the widely available cholesterol lowering statins. In this population-based case-control study, the frequencies of -911 C>A polymorphism (rs3761740) of the HMGCR gene in patients with coronary heart disease (CHD) and healthy subjects were investigated and the correlations between the different genotypes and hypercholesterolemia with cardiovascular risk factors were analyzed.
URI
http://hdl.handle.net/20.500.12627/72961
https://doi.org/10.1016/j.gene.2013.07.056
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