Synthesis, computational study, and evaluation of in vitro antimicrobial, antibiofilm, and anticancer activities of new sulfanyl aminonaphthoquinone derivatives
Date
2017Author
Kara, Emel Mataraci
Tuyun, Amaç Fatih
Bayrak, Nilufer
Yildirim, Hatice
Fujıta, Mikako
Celik, Berna Ozbek
Nasırı, Hamid R.
Otsuka, Masami
Cıftcı, Halil I.
Gupta, Girish Kumar
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Background: A set of novel sulfanyl aminonaphthoquinone derivatives (5a-j) were synthesized starting from 2,3-dichloro-1,4-naphthoquinone (1). The amine substituents were introduced via a nucleophilic substitution at reflux temperature. Subsequent reactions of 2-chloro-3-arylamino-1,4-naphthoquinones (3a-d) with different thiols (4a-c) led to the formation of the desired amino-and thio-substituted products (5a-j).
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