Histopathologic Changes in the Middle Ear Mucosa After Exposure to Pepsin and Unconjugated Bile Acid

Abstract

Objective: An increasing number of studies indicate that pepsin and bile acid cause damage to the ear, nose, and throat structures as a result of extraesophageal reflux. The aim of this study was to evaluate and compare the damaging effect of bile acids and pepsin on the middle ear mucosa.