The Factor V Leiden 1691G>A and Methylenetetrahydrofolate Reductase 677C>T Gene Mutations in Recurrent Fetal Loss: A Case and Review of the Literature Tekrarlayan gebelik kayiplarinda faktor v leiden 1691g>a ve metilentetrahidrofolat reduktaz 677c>t gen mutasyonlari: olgu sunumu ve literaturun gozden gecirilmesi

Abstract

Thrombophilia can be defined as a predisposition to form clots inappropriately. Throm bophilia is usually categorized into two types, acquired and genetic. The factor V Leiden (F VL) and methylenetetrahydrofolate reductase (MTHFR) gene mutations are genetic conditions which asso ciated with the recurrent fetal loss. In this case, the patient who has heterozigot F VL 1691G>A and MTHFR 677C>T gene mutations with the recurrent fetal loss is presented. The present of both F VL and MTHFR gene mutations increase the risk of thrombosis seriously. In conclusion, the preg nant who has two gene mutations must be observed carefully for recurrent fetal loss and thrombosis. Moreover, they should be investigated for the purposes of the antiagregan and anticoagulant (low molecular weight heparin) theraphy. In similar cases, the cardiologist, internal medicine specialist and gynecologist should be work in cooperation. Copyright © 2013 by Türkiye Klinik leri.