Heart Failure-Related Hyperphosphorylation in the Cardiac Troponin I C Terminus Has Divergent Effects on Cardiac Function In Vivo
Date
2017Author
Zhang, Pingbo
Murphy, Anne M.
Kass, David A.
Ramirez-Correa, Genaro
Keceli, Gizem
Heravi, Amir
Okumus, Nazli
Takahashi, Cyrus
Li, Yuejin
Zhu, Guangshuo
Paolocci, Nazareno
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BACKGROUND: In human heart failure, Ser199 (equivalent to Ser200 in mouse) of cTnI (cardiac troponin I) is significantly hyperphosphorylated, and in vitro studies suggest that it enhances myofilament calcium sensitivity and alters calpain-mediated cTnI proteolysis. However, how its hyperphosphorylation affects cardiac function in vivo remains unknown.
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