Impact of Neuro-Behcet Disease Immunoglobulin G on Neuronal Apoptosis

Abstract

Introduction: Parenchymal neuro-Behcet disease (NBD) is encountered in 5%-15% of Behcet disease (BD) patients and is characterized by inflammation of the brainstem and diencephalon structures. Neuronal apoptosis has been shown to participate in neuronal cell loss. Anti-neuronal antibodies have been identified in NBD patients. However, the pathogenic properties of these antibodies have not been studied.