Expression and cellular distribution of multidrug resistance-related proteins in patients with focal cortical dysplasia
Date
2007Author
Sar, Mehmet
Ozkara, Cigdem
Oz, Buge
Uzan, Mustafa
OZYURT, Emin
AK, Hatil
Tanriverdi, Taner
Sanus, Galip Zihni
Ay, Bahadır
IS, Merih
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Show full item recordAbstract
Recent arouse of interest indicated that drug resistant proteins are markedly over-expressed in the epileptogenic tissue and they may be responsible for the one-third of the epileptic patients who were refractory to anti-epileptic drugs (AEDs). Since several AEDs may act as substrates for these drug resistant proteins, the enhanced function of such proteins may increase drug extrusion, resulting in inadequate response to drug therapy in patients with epilepsy.
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