NEURAL REGENERATIVE NANOMEDICINE

Abstract

The administration of standardized exosomes secreted from stem cells under specific culture conditions and/or exosomes derived from stem cells designed to carry desired miRNAs, mRNAs, and proteins is promising for the treatment of many neurodegenerative diseases. However various barriers must be overcome before exosomes are applied in the clinic. For this reason, it is necessary to find a suitable method for the purification of exosomes that is scalable, compliant with CGMP guidelines, does not change the biological activity of them, and is effective to provide a homogeneous population of exosomes containing similar miRNAs, proteins, and lipids.