Association of Myeloperoxidase Gene Functional Variant with Schizophrenia and Smoking in a Turkish Population

Abstract

Objective: Etiopathogenesis of schizophrenia (SCZ) involves several risk genes that induce inflammation, environmental stress factors and changes in the innate immune system. Patients with SCZ have the highest rate of cigarette smoking and severe nicotine dependence. Myeloperoxidase (MPO), a member of subfamily of peroxidases, is most abundantly expressed in immune cells. The aim of this study was to investigate the relationship between the MPO rs2333227 variant and SCZ/smoking etiopathogenesis.