The Association of ABCC5 and ABCC11 Polymorphisms with The Pharmacokinetics of 5-FU in Advanced Gastric Cancer Patients

Date
2020
Author
Akyel, Yasemin Kubra
Ozhan, Gul
ÖZTÜRK, DİLEK
Turna, Hande
Okyar, Alper
Kara, Zeliha Pala
Oztas, Ezgi
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Abstract
Objective: Gastric cancer is the second leading cause of cancer-related deaths worldwide. 5-Fluorouracil (5-FU) is one of the most commonly used drugs to treat cancer, but 5-FU and its forms are characterized by wide inter-individual pharmacokinetic variability. ABCC5 and ABCC11 are members of the ABC transporter superfamily and play a role in the efflux of antineoplastic drugs like 5-FU.
URI
http://hdl.handle.net/20.500.12627/3690
https://doi.org/10.33808/clinexphealthsci.757619
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