The effects of alpha-lipoic acid on NOS dispersion in penis function of streptozotocin induced diabetic rats

Abstract

The aim of this study is to investigate the localization of NOS in normal and diabetic rats in the cavernose smooth muscles and to examine the effects of alpha-lipoic acid. Rats were divided into 4 groups as control, diabetic, diabetic +ALA applied, and only ALA. Tissues were examined by use of Masson trichrome, NADPH-d and eNOS. It was observed that ALA might play an important role in treatment of erectile dysfunction by decreasing iNOS and increasing the other isoforms of NOS.