Role of LRRK2 and SNCA in autosomal dominant Parkinson's disease in Turkey
Yazar
Pak, Meltem
Bilgic, Başar
Erginel-Unaltuna, Nihan
Gurvit, Hakan
Hanagasi, Haşmet Ayhan
KESSLER, Christoph
ATASU, Burcu
SIMON-SANCHEZ, Javier
HAUSER, Ann-Kathrin
GASSER, Thomas
LOHMANN, Ebba
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Introduction: Mutations in the LRRK2 and alpha-synuclein (SNCA) genes are well-established causes of autosomal dominant Parkinson's disease (PD). However, their frequency differs widely between ethnic groups. Only three studies have screened all coding regions of LRRK2 and SNCA in European samples so far. In Turkey, the role of LRRK2 in Parkinson's disease has been studied fragmentarily, and the incidence of SNCA copy number variations is unknown. The purpose of this study is to determine the frequency of LRRK2 and SNCA mutations in autosomal dominant PD in Turkey.
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- Makale [92796]