A method to evaluate microcirculatory vascular patency of full thickness burn in an animal model

Abstract

Background. In cases of thermal injuries it is always difficult to predict the extent of necrosis to the peripheral ischemic zone. Practically, full-thickness skin burn also affects the underlying muscle, panniculus carnosus, which adheres tightly to the skin. In this proposed model, the muscle which was always partly damaged also covers the ischemic zone of full-thickness burn injury. To evaluate the deeper Levels of injury, the status of the micro circulation of thermally affected muscle was evaluated by counting the accumulated radioactive agent, Tc-99m methoxyisobutylisonitril (MIBI) in the muscle cells.