Addition of topotecan to standard cisplatin/etoposide combination in patients with extended stage small cell lung carcinoma

Abstract

Background: Topotecan is an active agent for the management of untreated and recurrent extensive-disease small cell tung cancer, (ED-SCLC). This study was designed to evaluate the efficacy and safety of a triplet combination with topotecan added to the standard PE regimen in previously untreated patients with ED-SCLC.