The role of bicarbonate precursors in balanced fluids during haemorrhagic shock with and without compromised liver function

Abstract

Background: Lactate, acetate, and gluconate are anions used in balanced resuscitation fluids, of which lactate and acetate are considered bicarbonate precursors. This study investigated the role of the liver in the ability of balanced and unbalanced solutions to correct acid base alterations and renal haemodynamics and microvascular oxygenation in a rat model of resuscitated haemorrhagic shock.