Four Synchronous Tumors in One Patient: Breast, Endometrium, Ovarian and Fallopian Tube Cancer: Case Report

Abstract

Synchronous tumors in female genital tract are very rare and they account for 1-6% of all genital neoplasms. We present a 52-year old patient who was diagnosed and treated in our clinic and had synchronous breast, ovarian, endometrial and fallopian tube cancer. To our knowledge, this coincidence was reported for the first time in the literature. The patient was post-menopausal and presented with vaginal bleeding and a breast lump. She was subsequently diagnosed with endometrial cancer (stage 2B), ovarian or fallopian tube cancer (stage 3C) and breast cancer (stage 2A,T1c N0 M0). She received adjuvant chemotherapy and radiotherapy. On follow up after 2 years, she developed retroperitoneal, intraabdominal and hepatic metastatic lesions, therefore we planned to initiate systemic chemotherapy again. Synchronous gynecological malignancies were reported to have better prognosis in the literature, however as the tumors were at advanced stage in our patient, the recurrences developed earlier in the course. Therefore, close follow-up is recommended in patients with synchronous tumors in whom any of the tumors are at advanced stage.