Controlled release of methylene blue from layer-by-layer assembled chitosan/polyacrylic acid

Abstract

The electrostatic layer-by-layer (LbL) assembled multilayer films were widely used in the biomedical technology such as drug delivery. In this work, loading capabilities and release behavior of the multilayer films chitosan (Cts) and poly(acrylic acid) (PAA) were studied. The multilayer films were assembled by LbL technique through alternating deposition of Cts and PAA on glass slides, using methylene blue (MB) as a model drug. All the results showed that the LBL film's loading and release efficiency greatly controllable by pH and ionic strength of the solution. It suggested that the Cts/PAA LBL film had potential applications in drug delivery and controlled release studies.