A double-blind randomized controlled trial of topiramate and amitriptyline either alone or in combination for the prevention of migraine

Abstract

Objective: Effectiveness of antidepressants and antiepileptic drugs has already been demonstrated for migraine prophylaxis as monotherapy. In the present study, the efficacy and tolerability of amitriptyline and topiramate combination is examined in the prevention of migraine attacks, in comparison to the monotherapy of each drug.