Hypercapnia and surgical site infection: a randomized trial

Date
2013
Author
Iscoe, S.
Sessler, D. I.
Galandiuk, S.
Fisher, J.
Apfel, C. C.
Akca, O.
Kurz, A.
Fleischmann, E.
Buggy, D.
Herbst, F.
Stocchi, L.
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Abstract
Tissue oxygenation is a strong predictor of surgical site infection (SSI). Mild intraoperative hypercapnia increases peripheral, gastrointestinal, and splanchnic tissue oxygenation and perfusion. Hypercapnia also has anti-inflammatory effects. However, it is unknown whether hypercapnia reduces SSI risk. We tested the hypothesis that mild intraoperative hypercapnia reduces the risk of SSI in patients having colon resection surgery.
URI
http://hdl.handle.net/20.500.12627/24733
https://doi.org/10.1093/bja/aet233
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