Clinical Features of Candidiasis in Patients With Inherited Interleukin 12 Receptor beta 1 Deficiency

Date
2014
Author
KUMARARATNE, Dinakantha
AYTEKIN, Caner
HERRERA-RAMOS, Estefania
BHATTI, Micah
Karaca, Neslihan
BARBOUCHE, Ridha
BROIDES, Arnon
Goudouris, Ekaterini
LUIS FRANCO, Jose
PARVANEH, Nima
Reisli, Ismail
STRICKLER, Alexis
SHCHERBINA, Anna
Segal, Anthony
ANGEL-MORENO, Alfonso
LUIS LEZANA-FERNANDEZ, Jose
BEJAOUI, Mohamed
BOBADILLA-DEL VALLE, Miriam
KACHBOURA, Salem
SENTONGO, Timothy
BEN-MUSTAPHA, Imen
BUSTAMANTE, Jacinta
PICARD, Capucine
PUEL, Anne
BOISSON-DUPUIS, Stephanie
ABEL, Laurent
CASANOVA, Jean-Laurent
RODRIGUEZ-GALLEGO, Carlos
Somer, Ayper
OUEDERNI, Monia
Sanal, Ozden
Ikinciogullari, Aydan
Tezcan, Ilhan
Dogu, Figen
SOLOGUREN, Ithaisa
PEDRAZA-SANCHEZ, Sigifredo
Keser, Melike
TANIR, Gonul
Nieuwhof, Chris
COLINO, Elena
LEVY, Jacov
Kutukculer, Necil
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Abstract
Background. Interleukin 12R beta 1 (IL-12R beta 1)-deficient patients are prone to clinical disease caused by mycobacteria, Salmonella, and other intramacrophagic pathogens, probably because of impaired interleukin 12-dependent interferon gamma production. About 25% of patients also display mucocutaneous candidiasis, probably owing to impaired interleukin 23-dependent interleukin 17 immunity. The clinical features and outcome of candidiasis in these patients have not been described before, to our knowledge. We report here the clinical signs of candidiasis in 35 patients with IL-12R beta 1 deficiency.
URI
http://hdl.handle.net/20.500.12627/23329
https://doi.org/10.1093/cid/cit722
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