Evaluating the effectiveness of anti-tuberculosis treatment by detecting Mycobacterium tuberculosis 85B messenger RNA expression in sputum

Date
2020
Author
AKKUŞ, Seher
Ozbey, Dogukan
Kocak, Banu Tufan
Gareayaghi, Nesrin
Kirmusaoglu, Sahra
BAHAR TOKMAN, Hrisi
Kocazeybek, Bekir
Babalik, Aylin
Balikei, Ahmet
Satana, Dilek
ATAHAN, Ersan
Saribas, Suat
DEMİRCİ, MEHMET
Ziver, Tevhide
DİNÇ, HARİKA ÖYKÜ
Keskin, Melike
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Abstract
Background: The antigen 85 complex (85B) is secreted in large quantities from growing mycobacteria and the presence of bacterial mRNA is an indicator of cell viability. The quantitative detection of 85B mRNA expression levels can be used to assess the success of anti-tuberculosis treatment outcomes to detect viable mycobacteria cells. Therefore, we evaluated the levels of 85B mRNA of Mycobacterium tuberculosis strains in patients with pulmonary tuberculosis.
URI
http://hdl.handle.net/20.500.12627/21514
https://doi.org/10.1016/j.jiph.2020.05.016
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