Protective effect of melatonin and carnosine against radiation induced kidney injury

Abstract

We designed this study to determine possible protective roles of melatonin and carnosine on radiation. Wistar albino rats were divided to five groups. Melatonin, carnosine and combinated version were injected to Group III, IV and V every 48 h in a week. Group II, III, IV and V were exposed to 8 Gy gamma radiation dose arranged for whole-body one hour later second injection. Degenerative and biochemical changes were determined in radiation group as compared to control group. Administration of melatonin, carnosine and their combination ameliorated these parameters. We can conclude melatonin, carnosine and their combination protect kidney against radiation.