Sex differences in COVID-19 mortality risk in patients on kidney function replacement therapy
Date
2022Author
MohanKumar, N.
de Fijter, Carola W. H.
Mongera, Nicola
Pini, Stefano
de Biase, Consuelo
Kerckhoffs, Angele
van de Logt, Anne Els
Maas, Rutger
Hilbrands, Luuk B.
Lebedeva, Olga
Lopez, Veronica
Reichert, Louis J. M.
Verhave, Jacobien
Titov, Denis
Parshina, Ekaterina V.
Zanoli, Luca
Marcantoni, Carmelita
van Kempen, Gijs
van Gils-Verrij, Liesbeth E. A.
Harty, John C.
Meurs, Marleen
Myslak, Marek
Battaglia, Yuri
Lentini, Paolo
den Deurwaarder, Edwin
Stendahl, Maria
Rahimzadeh, Hormat
Rydzewski, Andrzej
Braconnier, Philippe
Weis, Daniel
Gellert, Ryszard
Oliveira, João
Alferes, Daniela G.
Zakharova, Elena V.
Ambühl, Patrice Max
Guidotti, Rebecca
Walker, Andrea
Lepeytre, Fanny
Rabaté, Clémentine
Rostoker, Guy
Marques, Sofia
Azasevac, Tijana
Majstorovic, Gordana Strazmester
Katicic, Dajana
ten Dam, Marc
Krüger, Thilo
Brzosko, Szymon
Liakopoulos, Vassilios
Zanen, Adriaan L.
Logtenberg, Susan J. J.
Fricke, Lutz
Kuryata, Olexandr
Slebe, Jeroen J. P.
ElHafeez, Samar Abd
Kemlin, Delphine
van de Wetering, Jacqueline
Reinders, Marlies E. J.
Hesselink, Dennis A.
Kal-van Gestel, J.
Eiselt, Jaromir
Kielberger, Lukas
El-Wakil, Hala S.
Verhoeven, Martine
Logan, Ian
Canal, Cristina
Facundo, Carme
Ramos, Ana M.
Debska-Slizien, Alicja
Veldhuizen, Nicoline M. H.
Tigka, Eirini
Konsta, Maria Anna Polyzou
Panagoutsos, Stylianos
Mallamaci, Francesca
Postorino, Adele
Cambareri, Francesco
Matceac, Irina
Nistor, Ionut
Groeneveld, J.H.M.
Jousma, Jolanda
van Buren, Marjolijn
Diekmann, Fritz
Oppenheimer, Federico
Blasco, Miquel
Pereira, Tiago Assis
Santos, Augusto Cesar S.
Arias-Cabrales, Carlos
Crespo, Marta
Llinàs-Mallol, Laura
Buxeda, Anna
Tàrrega, Carla Burballa
Redondo-Pachon, Dolores
Jimenez, Maria Dolores Arenas
Mendoza-Valderrey, Alberto
Martins, Ana Cristina
Mateus, Catarina
Alvila, Goncalo
Laranjinha, Ivo
Hofstra, Julia M.
Siezenga, Machiel A.
Franco, Antonio
Arroyo, David
Castellano, Sandra
Rodríguez-Ferrero, Maria Luisa
Manzanos, Sagrario Balda
Barrios, R. Haridian Sosa
Lemahieu, Wim
Bartelet, Karlijn
Dirim, Ahmet Burak
Rychlik, Ivan
Cabezas-Reina, Carlos J.
Roca, Ana Maria
Nauta, Ferdau
Sahin, İdris
Goffin, Eric
Kanaan, Nada
Labriola, Laura
Devresse, Arnaud
Diaz-Mareque, Anabel
Coca, Armando
de Arriba, Gabriel
Meijers, Björn K. I.
Naesens, Maarten
Kuypers, Dirk
Desschans, Bruno
Tonnerlier, Annelies
Wissing, Karl M.
Dedinska, Ivana
Pessolano, Giuseppina
Malik, Shafi
Dounousi, Evangelia
Papachristou, Evangelos
Berger, Stefan P.
Sanders, Jan Stephan F.
Franssen, Casper F. M.
Özyilmaz, Akin
Ponikvar, Jadranka Buturović
Pernat, Andreja Marn
Kovac, Damjan
Arnol, Miha
Ekart, Robert
Abrahams, Alferso C.
Molenaar, Femke M.
van Zuilen, Arjan D.
Meijvis, Sabine C. A.
Dolmans, Helma
Tantisattamo, Ekamol
Esposito, Pasquale
Krzesinski, Jean-Marie
Barahira, Jean Damacène
Gallieni, Maurizio
Martin-Moreno, Paloma Leticia
Guglielmetti, Gabriele
Guzzo, Gabriella
Toapanta, Nestor
Soler, Maria Jose
Luik, Antinus J.
van Kuijk, Willi H. M.
Stikkelbroeck, Lonneke W. H.
Hermans, Marc M. H.
Rimsevicius, Laurynas
Righetti, Marco
Islam, Mahmud
Radulescu, Daniela
Hengst, Maaike
Konings, Constantijn
Vart, Priya
Duivenvoorden, Raphaël
Adema, Aaltje
Covic, Adrian
Finne, Patrik
Braak, Nicole Heijtink-ter
Laine, Kaisa
Noordzij, Marlies
Schouten, Marcel
Jager, Kitty J.
Gansevoort, Ron T.
van der Net, Jeroen B.
Essig, Marie
du Buf-Vereijken, Peggy W. G.
van Ginneken, Betty
Maas, Nanda
van Jaarsveld, Brigit C.
Bemelman, Frederike J.
Klingenberg-Salahova, Farah
Heenan-Vos, Frederiek
Vervloet, Marc G.
Nurmohamed, Azam
Vogt, Liffert
Abramowicz, Daniel
Verhofstede, Sabine
Maoujoud, Omar
Malfait, Thomas
Fialova, Jana
Melilli, Edoardo
Favà, Alexandre
Cruzado, Josep M.
Perez, Nuria Montero
Lips, Joy
Krepel, Harmen
Adilovic, Harun
Demir, Erol
Sever, Mehmet Sukru
Turkmen, Aydin
Şafak, Seda
Hollander, Daan A. M. J.
Büttner, Stefan
de Vries, Aiko P. J.
Meziyerh, Soufian
van der Helm, Danny
Mallat, Marko
Bouwsma, Hanneke
Sridharan, Sivakumar
Petruliene, Kristina
Maloney, Sharon-Rose
Verberk, Iris
van der Sande, Frank M.
Christiaans, Maarten H. L.
Hemmelder, Marc H.
Di Luca, Marina
Tuğlular, Serhan Z.
Kramer, Andrea B.
Beerenhout, Charles
Luik, Peter T.
Kerschbaum, Julia
Tiefenthaler, Martin
Watschinger, Bruno
Stepanov, Vadim A.
Zulkarnaev, Alexey B.
Turkmen, Kultigin
Gandolfini, Ilaria
Maggiore, Umberto
Fliedner, Anselm
Åsberg, Anders
Mjoen, Geir
Miyasato, Hitoshi
Metadata
Show full item recordAbstract
© 2022, The Author(s).In the general population with COVID-19, the male sex is an established risk factor for mortality, in part due to a more robust immune response to COVID-19 in women. Because patients on kidney function replacement therapy (KFRT) have an impaired immune response, especially kidney transplant recipients due to their use of immunosuppressants, we examined whether the male sex is still a risk factor for mortality among patients on KFRT with COVID-19. From the European Renal Association COVID-19 Database (ERACODA), we examined patients on KFRT with COVID-19 who presented between February 1st, 2020, and April 30th, 2021. 1204 kidney transplant recipients (male 62.0%, mean age 56.4 years) and 3206 dialysis patients (male 61.8%, mean age 67.7 years) were examined. Three-month mortality in kidney transplant recipients was 16.9% in males and 18.6% in females (p = 0.31) and in dialysis patients 27.1% in males and 21.9% in females (p = 0.001). The adjusted HR for the risk of 3-month mortality in males (vs females) was 0.89 (95% CI 65, 1.23, p = 0.49) in kidney transplant recipients and 1.33 (95% CI 1.13, 1.56, p = 0.001) in dialysis patients (pinteraction = 0.02). In a fully adjusted model, the aHR for the risk of 3-month mortality in kidney transplant recipients (vs. dialysis patients) was 1.39 (95% CI 1.02, 1.89, p = 0.04) in males and 2.04 (95% CI 1.40, 2.97, p < 0.001) in females (pinteraction = 0.02). In patients on KFRT with COVID-19, the male sex is not a risk factor for mortality among kidney transplant recipients but remains a risk factor among dialysis patients. The use of immunosuppressants in kidney transplant recipients, among other factors, may have narrowed the difference in the immune response to COVID-19 between men and women, and therefore reduced the sex difference in COVID-19 mortality risk.
URI
http://hdl.handle.net/20.500.12627/185590https://doi.org/10.1038/s41598-022-22657-4
https://avesis.istanbul.edu.tr/api/publication/02022a62-fa02-4880-b360-fcd7524e353c/file
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