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Characteristics and outcomes of carbapenemase harbouring carbapenem-resistant Klebsiella spp. bloodstream infections: a multicentre prospective cohort study in an OXA-48 endemic setting

dc.contributor.authorTİGEN, ELİF
dc.contributor.authorAKOVA, MURAT
dc.contributor.authorPaterson, David L.
dc.contributor.authorCan, Fusun
dc.contributor.authorErgonul, Onder
dc.contributor.authorAZAP, ÖZLEM
dc.contributor.authorTÜLEK, NECLA
dc.contributor.authorDemirkaya, Hamiyet
dc.contributor.authorMenekse, Sirin
dc.contributor.authorAKALIN, EMİN HALİS
dc.contributor.authorBALKAN, İLKER İNANÇ
dc.contributor.authorAydin, Mehtap
dc.contributor.authorDemir, Safiye Koculu
dc.contributor.authorAZAP, ALPAY
dc.contributor.authorSALTOĞLU, NEŞE
dc.contributor.authorForde, Brian
dc.contributor.authorChatfield, Mark D.
dc.contributor.authorGonen, Mehmet
dc.contributor.authorBakir, Veli Oguzalp
dc.contributor.authorHAZIROLAN, GÜLŞEN
dc.contributor.authorYagci, Serap
dc.contributor.authorArabaci, Cigdem
dc.contributor.authorDogan, Ozlem
dc.contributor.authorKeske, Siran
dc.contributor.authorKapmaz, Mahir
dc.contributor.authorIsler, Burcu
dc.contributor.authorOzer, Berna
dc.contributor.authorÇINAR, GÜLE
dc.contributor.authorASLAN, ABDULLAH TARIK
dc.contributor.authorVatansever, Cansel
dc.contributor.authorFalconer, Caitlin
dc.contributor.authorDolapci, Istar
dc.contributor.authorSimsek, Funda
dc.date.accessioned2022-07-04T13:12:32Z
dc.date.available2022-07-04T13:12:32Z
dc.identifier.citationIsler B., Ozer B., ÇINAR G., ASLAN A. T. , Vatansever C., Falconer C., Dolapci I., Simsek F., TÜLEK N., Demirkaya H., et al., "Characteristics and outcomes of carbapenemase harbouring carbapenem-resistant Klebsiella spp. bloodstream infections: a multicentre prospective cohort study in an OXA-48 endemic setting", EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2022
dc.identifier.issn0934-9723
dc.identifier.othervv_1032021
dc.identifier.otherav_3ec0d2e3-9198-4619-9af9-f06de04adbf5
dc.identifier.urihttp://hdl.handle.net/20.500.12627/182429
dc.identifier.urihttps://doi.org/10.1007/s10096-022-04425-4
dc.description.abstractA prospective, multicentre observational cohort study of carbapenem-resistant Klebsiella spp. (CRK) bloodstream infections was conducted in Turkey from June 2018 to June 2019. One hundred eighty-seven patients were recruited. Single OXA-48-like carbapenemases predominated (75%), followed by OXA-48-like/NDM coproducers (16%). OXA-232 constituted 31% of all OXA-48-like carbapenemases and was mainly carried on ST2096. Thirty-day mortality was 44% overall and 51% for ST2096. In the multivariate cox regression analysis, SOFA score and immunosuppression were significant predictors of 30-day mortality and ST2096 had a non-significant effect. All OXA-48-like producers remained susceptible to ceftazidime-avibactam.
dc.language.isoeng
dc.subjectBULAŞICI HASTALIKLAR
dc.subjectTemel Bilimler
dc.subjectYaşam Bilimleri
dc.subjectMikrobiyoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectİmmünoloji
dc.subjectHealth Sciences
dc.subjectLife Sciences
dc.subjectInfectious Diseases
dc.subjectImmunology
dc.subjectGeneral Immunology and Microbiology
dc.titleCharacteristics and outcomes of carbapenemase harbouring carbapenem-resistant Klebsiella spp. bloodstream infections: a multicentre prospective cohort study in an OXA-48 endemic setting
dc.typeMakale
dc.relation.journalEUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
dc.contributor.departmentUniversity of Queensland , ,
dc.contributor.firstauthorID3403222


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