Characteristics and outcomes of carbapenemase harbouring carbapenem-resistant Klebsiella spp. bloodstream infections: a multicentre prospective cohort study in an OXA-48 endemic setting

Author
TİGEN, ELİF
AKOVA, MURAT
Paterson, David L.
Can, Fusun
Ergonul, Onder
AZAP, ÖZLEM
TÜLEK, NECLA
Demirkaya, Hamiyet
Menekse, Sirin
AKALIN, EMİN HALİS
BALKAN, İLKER İNANÇ
Aydin, Mehtap
Demir, Safiye Koculu
AZAP, ALPAY
SALTOĞLU, NEŞE
Forde, Brian
Chatfield, Mark D.
Gonen, Mehmet
Bakir, Veli Oguzalp
HAZIROLAN, GÜLŞEN
Yagci, Serap
Arabaci, Cigdem
Dogan, Ozlem
Keske, Siran
Kapmaz, Mahir
Isler, Burcu
Ozer, Berna
ÇINAR, GÜLE
ASLAN, ABDULLAH TARIK
Vatansever, Cansel
Falconer, Caitlin
Dolapci, Istar
Simsek, Funda
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Abstract
A prospective, multicentre observational cohort study of carbapenem-resistant Klebsiella spp. (CRK) bloodstream infections was conducted in Turkey from June 2018 to June 2019. One hundred eighty-seven patients were recruited. Single OXA-48-like carbapenemases predominated (75%), followed by OXA-48-like/NDM coproducers (16%). OXA-232 constituted 31% of all OXA-48-like carbapenemases and was mainly carried on ST2096. Thirty-day mortality was 44% overall and 51% for ST2096. In the multivariate cox regression analysis, SOFA score and immunosuppression were significant predictors of 30-day mortality and ST2096 had a non-significant effect. All OXA-48-like producers remained susceptible to ceftazidime-avibactam.
URI
http://hdl.handle.net/20.500.12627/182429
https://doi.org/10.1007/s10096-022-04425-4
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