Real life experience of patients with locally advanced gastric and gastroesophageal junction adenocarcinoma treated with neoadjuvant chemotherapy: a Turkish oncology group study
Yazar
Gulmez, Ahmet
Ayhan, Murat
Inal, Ali
Salim, Derya Kivrak
Deniz, Gulhan Ipek
Sakalar, Teoman
Tataroglu ozyukseler, Deniz
Kacan, Turgut
Ozdemir, Ozlem
Alan, Ozkan
Unal, Caglar
Karakas, Yusuf
Turhal, Serdar
YUMUK, PERRAN FULDEN
BAŞOĞLU TÜYLÜ, TUĞBA
Sakin, Abdullah
Erol, Cihan
Ozden, Ercan
ÇABUK, DEVRİM
Cilbir, Ebru
Sendur, Mehmet Ali
Dogan, Mutlu
Oksuzoglu, Berna
Eryilmaz, Melek Karakurt
ER, Ozlem
Tasci, Elif Senocak
Ozyurt, Neslihan
Dulgar, Ozgecan
Ozen, Mirac
HACIBEKİROĞLU, İLHAN
Oner, Irem
Bekmez, Esma Turkmen
Cagri Yildirim, Hasan
YALÇIN, ŞUAYİB
PAYDAŞ, SEMRA
Yekeduz, Emre
AKSOY, ASUDE
Ozcelik, Melike
Oyman, Abdilkerim
Almuradova, Elvina
KARABULUT, BÜLENT
DEMİR, NAZAN
DİNCER, MURAT
ÖZDEMİR, NURİYE
Erdem, Dilek
Ak, Naziye
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Neoadjuvant chemotherapy (NACT) in gastroesophageal junction (GEJ) and gastric cancer (GC) was shown to improve survival in recent studies. We aimed to share our real-life experience of patients who received NACT to compare the efficacy and toxicity profile of different chemotherapy regimens in our country. This retrospective multicentre study included locally advanced GC and GEJ cancer patients who received NACT between 2007 and 2021. Relation between CT regimens and pathological evaluation were analysed. A total of 794 patients from 45 oncology centers in Turkey were included. Median age at the time of diagnosis was 60 (range: 18-86). Most frequent NACT regimens used were FLOT (65.4%), DCF (17.4%) and ECF (8.1%), respectively. In the total study group, pathological complete remission (pCR) rate was 7.2%, R0 resection rate 86.4%, and D2 dissection rate was 66.8%. Rate of pCR and near-CR (24%), and R0 resection (84%) were numerically higher in FLOT arm (p > 0.05). Patients who received FLOT had also higher chemotherapy-related toxicity rate compared to patients who received other regimens (p > 0.05). Median follow-up time was 16 months (range: 1-154 months). Estimated median overall survival (OS) was 58.4months (95% CI: 35.2-85.7) and disease-free survival (DFS) was 50.7 months (95% CI: 25.4-75.9). The highest 3-year estimated OS rate was also shown in FLOT arm (68%). We still do not know which NACT regimen is the best choice for daily practice. Clinicians should tailor treatment regimens according to patients' multifactorial status and comorbidities for to obtain best outcomes. Longer follow-up period needs to validate our results.
Bağlantı
http://hdl.handle.net/20.500.12627/181496https://doi.org/10.1080/1120009x.2022.2073159
https://avesis.istanbul.edu.tr/api/publication/07be9860-a99f-4369-b0c2-4274fbb4a5c7/file
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