EVALUATION OF PLASMANITRATE/NITRITE LEVELS IN PATIENTS WITH ACNE VULGARIS

Abstract

Objective: Acne is characterized by open and close comedon, erythematous papules, pustules, pseudocysts, nodules and scar formation. Factors playing role at the etiopathogenesis include increased sebum secretion, ductal hyperkeratinization (hypercornification), Propionibacterium Acnes colonization at the follicules and inflammation. Nitric oxide (NO) is an inorganic molecule which is synthesized by NO synthetase (NOS) found in keratinocyte, fibroblast, endothel, Langerhans and mast cells of the skin. NOS found in the keratinocytes and mast cells is induced by cytokines. Produced NO stimulates guanylate cyclase which increases cGMP levels; cGMP has mitogenic effects on keratinocytes and mast cells, therefore causes hyperkeratinization. The aim of this study was to evaluate the role of nitric oxide levels in the etiopathogenesis of acne vulgaris.