Paving the way for applying GLIM criteria in clinical practice and research: how to define mild to moderate and severe reduced muscle mass

Abstract

Key summary pointsAim To report grade 1 and grade 2 reduced muscle mass cut-offs for skeletal muscle mass (SMM) adjusted by body mass index (BMI) to increase the applicability of the GLIM criteria. Findings Grade 1 vs. grade 2 low muscle mass (LMM) thresholds were 1.189 and 0.954 kg/BMI vs. 1.049 and 0.823 kg/BMI in males and females, respectively. Message While validation studies are needed to evaluate their predictive ability, our approach presented here seems applicable and the cut-off values acceptable for use until population-specific values in different populations or global generic cut-offs are identified.