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Evaluation of cytotoxic and genotoxic effects of Benodanil by using Allium and Micronucleus assays

Date
2016
Author
KONUK, MUHSİN
DAĞOĞLU SAKİN, Rabia Nergiz
AKYIL, DİLEK
ÖZKARA, ARZU
ERDOĞMUŞ, SEVİM FEYZA
Eren, Yasin
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Abstract
The aim of this study was to evaluate the potential cytotoxic effects of Benodanil fungicide by employing both mitotic index (MI) and mitotic phases on the root meristem cells of Allium cepa and genotoxic effects by using in vitro micronucleus assay (MN) in human peripheral blood lymphocyte. In the Allium root growth inhibition test, the EC50 value was first determined as 25ppm. Then, 2xEC(50) value (50ppm), EC50 value (25ppm), and 1/2xEC(50) value (12.5ppm) were tested with different treatment periods (24, 48, and 72h). Both negative and positive controls were also used in parallel experiments. We obtained that mitotic index and prophase index decreased when compared with the control in all concentrations. In the micronucleus assay, lymphocytes were treated with various concentrations (250, 500, 750, and 1000 mu g/ml) of Benodanil for 24 and 48h. The results showed that Benodanil did not induce MN frequency in all concentrations of both treatment periods. Additionally, it was determined that this pesticide decreased nuclear division index (NDI) significantly. It was concluded that Benodanil has a cytotoxic effects depending on decreasing of MI and NDI.
URI
http://hdl.handle.net/20.500.12627/177459
https://doi.org/10.3109/01480545.2015.1012211
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Creative Commons Lisansı

İstanbul Üniversitesi Akademik Arşiv Sistemi (ilgili içerikte aksi belirtilmediği sürece) Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

DSpace software copyright © 2002-2016  DuraSpace
Contact Us | Send Feedback
Theme by 
Atmire NV