In search of pulmonary hypertension treatments: Effect of 17 beta-estradiol on PGI(2) pathway in human pulmonary artery

Author
Tran-Dinh, Alexy
Castier, Yves
Guyard, Alice
Longrois, Dan
Silverstein, Adam M.
Norel, Xavier
Ozen, Gulsev
Amgoud, Yasmine
Senbel, Amira
Bouhadoun, Amel
Abdelazeem, Heba
Savane, Ines
Manikpurage, Hasanga D.
Mani, Salma
Metadata
Show full item record
Abstract
Introduction: Prostacyclin (PGI(2)) is synthetized by PGI(2) synthase (PGIS) and induces vasorelaxation via activation of cyclic AMP (cAMP) generating IP-receptor. Several components of the PGI(2) signaling pathway are reduced in patients with pulmonary hypertension (PH).
URI
http://hdl.handle.net/20.500.12627/175412
https://doi.org/10.1016/j.plefa.2021.102321
Collections