Update on Chronic Renal Failure and New Approaches in Hypertension In High Dose Renin-Angiotensin-Aldosteron System Blockage

Abstract

Hypertension (HT) and chronic renal failure, which is one of the end organ damges of hypertension, is a very carnmon social program resulting in significat morbidty and mortality of HT. In uncompticated HT, the traget blood pressure should be below 140/90mmHg. This value even drops down to 125/75 mmHg in case of traget organ damange When the traget values cannot be achieved , anti hypertensive durg therpy should be arranged in addition to non pharmacological therapeutic approaches such as changes in life style. individualized therapy protocals are preffered today in drug selection instead of step therapy ,which was common 30-40 years ago, taking into account the adverse effects of drugs, and the diseases accompanying HT. In recent years it is demonstated that in especially patients with chronic renal failure accompanied by proteinuria. the combined or high dose use of drugs inhibiting the renin-angiotensin system delays development of the renal damage, and decreases mortality and morbidity. Today, high doses of angiotensin receptor blocker (ARB) drugs particularly used.