Childhood Rhabdomyosarcoma of the Female Genital Tract: Association with Pathogenic DICER1 Variation, Clinicopathological Features, and Outcomes

Date
2021
Author
Onder, Semen
Yilmaz, Ismail
Iribas, Ayca
Arndt, Carola A.
Harris, Anne K.
Field, Amanda
Schultz, Kris Ann P.
Hill, D. Ashley
Bilgic, Bilge
Kebudi, Rejin
Dural, Ozlem
Bay, Sema Buyukkapu
Gorgun, Omer
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Abstract
Study Objective: Rhabdomyosarcomas (RMSs) of the female genital tract (FGT) have been recently shown to be associated with germline pathogenic variation in DICER1, which can underlie a tumor predisposition disorder. We sought to determine the incidence of a pathogenic variation in DICER1 in a cohort of RMSs of the FGT, as well as to evaluate the clinicopathological features and outcomes of the patients.
URI
http://hdl.handle.net/20.500.12627/173767
https://doi.org/10.1016/j.jpag.2021.01.011
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