Association of HLA-DRB1 Alleles and Autoimmune Hepatitis in Turkish Patients
Date
2010Author
Karahan, Gonca Emel
Kekik, Cigdem
Pinarbasi, Binnur
Seyhun, Yalcin
Kaymakoglu, Sabahattin
Demir, Kadir
Carin, Mahmut
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Objectives: Autoimmune hepatitis (AIH) which is characterized by hypergammaglobulinemia and a wide range of circulating auto antibodies is a necro-inflammatory liver disease of unknown aetiology. Immunogenetic studies have shown the association of autoimmunity with HLA (Human Leukocyte Antigen) alleles. Furthermore, they have shown a decrease in the expression of HLA antigens on lymphocyte surface and a dysregulation of gene expression arranged by HLA. A significant association is found between AIH and HLA-DRB1(star)03, (star)04 and (star)13 alleles in various studies. We performed HLA-DRB1 genotyping in Turkish patients with AIH.
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