Long term follow-up of hyperimmunoglobulin M syndrome cases

Abstract

Objective: Hyperimmunoglobulin M (HIGM) syndromes are primary immunodeficiencies characterized by normal or elevated serum IgM levels with decreased levels of other immunoglobulin isotypes. Over the past decade rapid progress has been made in the molecular and genetic basis of HIGM and five distinct subgroups have been described.